卡前列素氨丁三醇联合卡贝缩宫素对剖宫产后出血患者NO、NOS、FIB、D-dimer

卡前列素氨丁三醇联合卡贝缩宫素对剖宫产后出血患者NO、NOS、FIB、D-dimer及泌乳功能的影响(论文5000字)
 [摘要]目的：研究卡前列素氨丁三醇联合卡贝缩宫素对剖宫产后出血患者一氧化氮（NO）、一氧化氮合酶（NOS）、纤维蛋白原( FIB)、D-二聚体( D-dimer)及泌乳功能的影响。方法：选取我院2015年6月至2017年6月具有剖宫产手术指证的孕产妇119例，分为观察组和对照组，对照组给予注射卡前列素氨丁三醇治疗，观察组给予注射卡前列素氨丁三醇联合卡贝缩宫素治疗。观察两组治疗后临床疗效，并检测治疗前后NO、NOS、FIB、D-dimer水平以及泌乳功能。结果：治疗后，观察组子宫复旧有效率为93.2%明显高于对照组子宫复旧有效率74.6%，差异显著（P<0.05）；观察组NO、NOS、FIB、D-dimer水平均显著低于对照组，比较具有统计学意义（P<0.05）；观察组术后2h出血量、术后24h出血量、产后出血率、宫缩持续时间及恶露持续时间均低于对照组，比较具有统计学意义（P<0.05）；观察组泌乳时间低于对照，观察组产后1d泌乳量评分及产后2d泌乳量评分均高于对照组，比较具有统计学意义（P<0.05）。结论:卡前列素氨丁三醇联合卡贝缩宫素治疗剖宫产产后出血患者，有效降低患者NO、NOS、FIB、D-dimer水平及2h出血量、术后24h出血量、产后出血率、宫缩持续时间及恶露持续时间，改善患者泌乳时间，提高患者1d泌乳量评分及产后2d泌乳量评分。
【关键词】卡前列素氨丁三醇；卡贝缩宫素；NO；FIB；D-dimer；NOS；剖宫产产后出血
中图分类号：R714.62    文献标识码：A    文章编号：
Effects of caffeine tromethamine combined with carbene oxytocin on NO, NOS, FIB, D-dimer and lactation in patients with postpartum hemorrhage
[Abstract] Objective: To study effects of caffeine tromethamine combined with carbene oxytocin on NO, NOS, FIB, D-dimer and lactation in patients with postpartum hemorrhage. Methods: 118 patients of cesarean section bleeding whoreceived therapy from June 2015 to June 2017in our hospital wereselected as research objects. According to different treatment options，those patients were divided into the control group ( n = 59) and the observation group ( n = 59)，the control group was treated withCard prostaglandin tromethamine drug therapy, while the observation group was treated with Prostaglandin tromethamine combined with carbene oxytocin, the clinical efficacy of the two groups was observed and the levels of NO, NOS, FIB, D-dimer and lactation were measured before and after treatment. Results: After treatment, the effective rate of uterine recovery was 93.2% in the observation group, which was significantly higher than that in the control group (74.6%). The difference was significant (P <0.05).the levels of NO, NOS, FIB and D-dimer in the observation group were significantly lower than those in the control group (P <0.05). the time of lactation in the observation group was lower than that in the control group (P <0.05), and the time of postoperative hemorrhage, postpartum hemorrhage rate, duration of uterine contusion and duration of lochia were lower than those of the control group (P <0.05). The scores of lactation and postpartum 2d lactation were significantly higher in the observation group than in the control group (P <0.05).Conclusion: the levels of NO, NOS, FIB, D-dimer and 2h bleeding in patients with postpartum hemorrhage were significantly lower than those in patients with postpartum hemorrhage. Duration and duration of lochia, improve the time of lactation, improve the 1d lactation score and postpartum 2d lactation score.
 key words Pentoprostin; Cobia oxytocin; NO; FIB; D-dimer; NOS; cesarean section postpartum hemorrhage
Chinese Library Classification(CLC): R714.62  Document code: A